Below is the output of my command.
[root@server /]# mail
"/var/spool/mail/root": 1832 messages 1777 new 1832 unread
fseek: Invalid argument
panic: temporary file seek
After a little bit of searching online I found two possible and simple solutions.
If you want to read the mail try using mutt instead of mail. It doesn't have a problem with the 2GB file size of the mail box that mail did.
If you don't care about the old stuff you can run:
rm -f /var/spool/mail/root
to remove the file and then
cat /dev/null > /var/spool/mail/root
to recreate a blank file.
I ended up reading the mail I wanted and then blowing the file away. But before I could recreate it there was already a new file with 62MB of mail in it.